An evaluation of Wb123 antibody elisa in individuals treated with ivermectin and albendazole, and implementation challenges in Africa.
Identifieur interne : 000788 ( Main/Exploration ); précédent : 000787; suivant : 000789An evaluation of Wb123 antibody elisa in individuals treated with ivermectin and albendazole, and implementation challenges in Africa.
Auteurs : Dziedzom Komi De Souza [Ghana] ; Irene Offei Owusu [Ghana] ; Joseph Otchere [Ghana] ; Michelle Adimazoya [Ghana] ; Kwadwo Frempong [Ghana] ; Collins Stephen Ahorlu [Ghana] ; Daniel Adjei Boakye [Ghana] ; Michael David Wilson [Ghana]Source :
- The Pan African medical journal [ 1937-8688 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Albendazole (administration et posologie), Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Antihelminthiques (administration et posologie), Enfant, Facteurs de l'âge, Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (traitement médicamenteux), Humains, Immunochromatographie (), Ivermectine (administration et posologie), Jeune adulte, Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA (), Wuchereria bancrofti (immunologie), Études transversales.
- MESH :
- administration et posologie : Albendazole, Antihelminthiques, Ivermectine.
- diagnostic : Filariose lymphatique.
- immunologie : Filariose lymphatique, Wuchereria bancrofti.
- sang : Anticorps antihelminthe, Antigènes d'helminthe.
- traitement médicamenteux : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Facteurs de l'âge, Humains, Immunochromatographie, Jeune adulte, Sujet âgé, Sujet âgé de 80 ans ou plus, Test ELISA, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Albendazole (administration & dosage), Animals, Anthelmintics (administration & dosage), Antibodies, Helminth (blood), Antigens, Helminth (blood), Child, Cross-Sectional Studies, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay (methods), Humans, Immunochromatography (methods), Ivermectin (administration & dosage), Middle Aged, Wuchereria bancrofti (immunology), Young Adult.
- MESH :
- chemical , administration & dosage : Albendazole, Anthelmintics, Ivermectin.
- chemical , blood : Antibodies, Helminth, Antigens, Helminth.
- diagnosis : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- methods : Enzyme-Linked Immunosorbent Assay, Immunochromatography.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Animals, Child, Cross-Sectional Studies, Humans, Middle Aged, Young Adult.
Abstract
The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation. In pre-treatment surveys, individuals were tested for antigen using the immuno-chromatographic test (ICT) card, and night blood microfilariae, after which all positives were treated using Ivermectin and Albendazole. The Wb123 ELISA was tested in antigen positive individuals, three months after they were treated. Samples were also tested for ICT and night blood microfilariae. The results revealed a reduction in microfilariae and ICT prevalence after treatment. Antigen and antibody prevalence increased with age. However, there was no correlation with the antibody responses observed. The mean WB123 antibody titers were higher among ICT positives, but not significantly different from ICT negative persons. While the Wb123 is targeted for use in untreated populations, further evaluations and guidelines will be required to define its use in populations that have undergone treatment for the control of LF.
DOI: 10.11604/pamj.2017.27.65.11004
PubMed: 28819487
Affiliations:
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(drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Humans</term><term>Immunochromatography (methods)</term><term>Ivermectin (administration & dosage)</term><term>Middle Aged</term><term>Wuchereria bancrofti (immunology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Albendazole (administration et posologie)</term><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (sang)</term><term>Antihelminthiques (administration et posologie)</term><term>Enfant</term><term>Facteurs de l'âge</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Immunochromatographie ()</term><term>Ivermectine (administration et posologie)</term><term>Jeune adulte</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Test ELISA ()</term><term>Wuchereria bancrofti (immunologie)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Albendazole</term><term>Anthelmintics</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Albendazole</term><term>Antihelminthiques</term><term>Ivermectine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Immunochromatography</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Cross-Sectional Studies</term><term>Humans</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Facteurs de l'âge</term><term>Humains</term><term>Immunochromatographie</term><term>Jeune adulte</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Test ELISA</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation. In pre-treatment surveys, individuals were tested for antigen using the immuno-chromatographic test (ICT) card, and night blood microfilariae, after which all positives were treated using Ivermectin and Albendazole. The Wb123 ELISA was tested in antigen positive individuals, three months after they were treated. Samples were also tested for ICT and night blood microfilariae. The results revealed a reduction in microfilariae and ICT prevalence after treatment. Antigen and antibody prevalence increased with age. However, there was no correlation with the antibody responses observed. The mean WB123 antibody titers were higher among ICT positives, but not significantly different from ICT negative persons. While the Wb123 is targeted for use in untreated populations, further evaluations and guidelines will be required to define its use in populations that have undergone treatment for the control of LF.</div></front></TEI><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="De Souza, Dziedzom Komi" sort="De Souza, Dziedzom Komi" uniqKey="De Souza D" first="Dziedzom Komi" last="De Souza">Dziedzom Komi De Souza</name></region><name sortKey="Adimazoya, Michelle" sort="Adimazoya, Michelle" uniqKey="Adimazoya M" first="Michelle" last="Adimazoya">Michelle Adimazoya</name><name sortKey="Ahorlu, Collins Stephen" sort="Ahorlu, Collins Stephen" uniqKey="Ahorlu C" first="Collins Stephen" last="Ahorlu">Collins Stephen Ahorlu</name><name sortKey="Boakye, Daniel Adjei" sort="Boakye, Daniel Adjei" uniqKey="Boakye D" first="Daniel Adjei" last="Boakye">Daniel Adjei Boakye</name><name sortKey="Frempong, Kwadwo" sort="Frempong, Kwadwo" uniqKey="Frempong K" first="Kwadwo" last="Frempong">Kwadwo Frempong</name><name sortKey="Otchere, Joseph" sort="Otchere, Joseph" uniqKey="Otchere J" first="Joseph" last="Otchere">Joseph Otchere</name><name sortKey="Owusu, Irene Offei" sort="Owusu, Irene Offei" uniqKey="Owusu I" first="Irene Offei" last="Owusu">Irene Offei Owusu</name><name sortKey="Wilson, Michael David" sort="Wilson, Michael David" uniqKey="Wilson M" first="Michael David" last="Wilson">Michael David Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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